| Cat. No. |
Product Name |
Information |
| PC-62391 |
AEM2
SIRT2 inhibitor
|
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2. |
| PC-61906 |
MIND-4
SIRT2 inhibitor, NRF2 inducer
|
MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway. |
| PC-60825 |
YK-3-237
SIRT1 activator
|
YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53. |
| PC-70105 |
Tenovin-D3
SIRT2 inhibitor
|
Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM. |
| PC-60124 |
SirReal1
Sirt2 inhibitor
|
SirReal1 is novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 3.745 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM). |
| PC-60123 |
SirReal2
Sirt2 inhibitor
|
SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM. |
| PC-60122 |
MZ242
SIRT2 inhibitor
|
MZ242 is a novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM). |
| PC-42642 |
SRT 1720
SIRT1 activator
|
SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM. |
| PC-45037 |
AK-7
SIRT2 inhibitor
|
AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM. |
| PC-42395 |
AK-1
SIRT2 inhibitor
|
AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM. |
| PC-42309 |
Salermide
Sirtuin inhibitor
|
Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively. |
| PC-23601 |
SIRT6 inhibitor 10d
SIRT6 inhibitor
|
SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM. |
