JH-T4 | SIRT2 inhibitor | Probechem Biochemicals

Chemical Structure : JH-T4

加入收藏

JH-T4 (SIRT2 inhibitor JH-T4)

货号: PC-36070Not For Human Use, Lab Use Only.

JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation.
JH-T4 inhibited both the deacetylation and defatty-acylation activity of SIRT2 in vitro with IC50 of 30-50 nM.
JH-T4 is the first small molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a.
JH-T4 also inhibits SIRT1 and SIRT3 in vitro.

物理化学性质&存储条件

分子量	597.859
分子式	C34H51N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl (S)-(1-((3-hydroxyphenyl)amino)-1-oxo-6-tetradecanethioamidohexan-2-yl)carbamate

参考文献

1. Spiegelman NA, et al. ChemMedChem. 2019 Feb 7. doi: 10.1002/cmdc.201800715.

JH-T4 (SIRT2 inhibitor JH-T4)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JH-T4 (SIRT2 inhibitor JH-T4)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.