UBCS039 | SIRT6 activator | Probechem Biochemicals

Chemical Structure : UBCS039

CAS No.: 358721-70-7

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UBCS039 (UBCS-039, UBCS 039)

货号: PC-35856Not For Human Use, Lab Use Only.

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
UBCS039 shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities.
UBCS039 induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.

物理化学性质&存储条件

分子量	247.301
分子式	C16H13N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

参考文献

1. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011.

2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24;9(10):996.

UBCS039 (UBCS-039, UBCS 039)

生物&药学活性

物理化学性质&存储条件

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UBCS039 (UBCS-039, UBCS 039)

生物&药学活性

物理化学性质&存储条件

参考文献

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