Tenovin-1 |CAS:380315-80-0 Probechem Biochemicals

Chemical Structure : Tenovin-1

CAS No.: 380315-80-0

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Tenovin-1 (Tenovin 1)

货号: PC-43528Not For Human Use, Lab Use Only.

Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
25 mg	￥780	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2.
Tenovin-1 causes significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 MyLa cells when combined with vorinostat.
Tenovin-1 elicits caspase-mediated cell death in p53 wild-type cells, but caspase-independent cell death in p53 null cells.

物理化学性质&存储条件

分子量	369.4805
分子式	C20H23N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-

参考文献

1. Lain S, et al. Cancer Cell. 2008 May;13(5):454-63.

2. Sonnemann J, et al. Br J Cancer. 2014 Feb 4;110(3):656-67.

3. Nihal M, et al. Cell Cycle. 2014;13(4):632-40. doi: 10.4161/cc.27523.

4. Marx C, et al. Invest New Drugs. 2018 Jun;36(3):396-406.

Tenovin-1 (Tenovin 1)

生物&药学活性

物理化学性质&存储条件

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Tenovin-1 (Tenovin 1)

生物&药学活性

物理化学性质&存储条件

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