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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -DK1-04
DK1-04

Chemical Structure : DK1-04

CAS No.: 2760692-55-3

DK1-04 (SIRT5 inhibitor DK1-04)

货号: PC-38160Not For Human Use, Lab Use Only.

DK1-04 is a potent, selective, cell-permeable small-molecule SIRT5 inhibitor with IC50 of 0.34 uM, shows no inhibition on SIRT1-3/6 at 83 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DK1-04 is a potent, selective, cell-permeable small-molecule SIRT5 inhibitor with IC50 of 0.34 uM, shows no inhibition on SIRT1-3/6 at 83 uM.

    物理化学性质&存储条件

    分子量 615.746
    分子式 C30H41N5O7S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (5S,8S)-8-((3-hydroxyphenyl)carbamoyl)-5-isobutyl-3,6-dioxo-1-phenyl-14-thioxo-2-oxa-4,7,13,15-tetraazaoctadecan-18-oic acid

    参考文献

    1. Yashira L Negrón Abril, et al. Oncogene. 2021 Mar;40(9):1644-1658.

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