MDL-800 | SIRT6 activator | Probechem Biochemicals

Chemical Structure : MDL-800

CAS No.: 2275619-53-7

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MDL-800 (MDL800)

货号: PC-35760Not For Human Use, Lab Use Only.

MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays.
MDL-800 dramatically enhanced SIRT6 deacetylation activity by more than 22-fold, displays no activity toward SIRT1, SIRT3, SIRT4, and HDAC1-11 at 50-100 uM, as well as >10-fold selectivity toward SIRT2, SIRT5, and SIRT7.
MDL-800activates SIRT6 through a surface allosteric site induces H3K9ac and H3K56ac deacetylation and represses proliferation of HCC cells (IC50=23.3 uM).
MDL-800 inhibits xenograft tumor growth of HCC cells in immunocompromised mice by activating the deacetylase activity of SIRT6.

物理化学性质&存储条件

分子量	626.289
分子式	C21H16BrCl2FN2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-((3,5-dichlorophenyl)sulfonamido)benzoate

参考文献

1. Huang Z, et al. Nat Chem Biol. 2018 Oct 29. doi: 10.1038/s41589-018-0150-0.

MDL-800 (MDL800)

生物&药学活性

物理化学性质&存储条件

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MDL-800 (MDL800)

生物&药学活性

物理化学性质&存储条件

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