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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -SRTCX1002
SRTCX1002

Chemical Structure : SRTCX1002

CAS No.: 1203479-63-3

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SRTCX1002 (SRTCX-1002)

货号: PC-35523Not For Human Use, Lab Use Only.

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.
    SRTCX1002 suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.

    物理化学性质&存储条件

    分子量 405.476
    分子式 C21H19N5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[3-(4-Morpholinyl)phenyl]-N-2-thiazolyl-1H-benzimidazole-7-carboxamide

    参考文献

    1. Yang H, et al. PLoS One. 2012;7(9):e46364.

    2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.

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