MK-1468 | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : MK-1468

加入收藏

MK-1468 (MK1468)

货号: PC-21271Not For Human Use, Lab Use Only.

MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.
MK-1468 demonstrates near-equipotent activity for LRRK2 (G2019S) and wild-type LRRK2.
MK-1468 is >100-fold selective against 265 off-target kinases tested, and >1000-fold selectivity against a panel of 117 functional, enzyme, and radioligand binding assays screened (Cerep, Panlabs).
MK-1468 inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in the rat brain, orally active.

物理化学性质&存储条件

分子量	501.02
分子式	C26H33ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(7-chloro-6-(4-((3R,4R)-4-hydroxy-3-methyltetrahydrofuran-3-yl)piperazin-1-yl)isoquinolin-3-yl)-6-oxaspiro[2.5]octane-1-carboxamide

参考文献

1. Kattar SD, et al. J Med Chem. 2023 Oct 20. doi: 10.1021/acs.jmedchem.3c01486.

MK-1468 (MK1468)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MK-1468 (MK1468)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.