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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-CZC-25146
CZC-25146

Chemical Structure : CZC-25146

CAS No.: 1191911-26-8

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CZC-25146 (CZC25146)

货号: PC-22263Not For Human Use, Lab Use Only.

CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively.
CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
CZC-25146 attenuates G2019S LRRK2-induced human neuronal injury with EC50 of 4 nM, completely blocks G2019S LRRK2 and R1441C-induced toxicity at higher concentrations.

物理化学性质&存储条件

分子量 488.54
分子式 C22H25FN6O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((5-Fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide

参考文献

1. Ramsden N, et al. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

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