LRRK2 inhibitor 25 | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : LRRK2 inhibitor 25

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LRRK2 inhibitor 25 (LRRK2-IN-7)

货号: PC-49823Not For Human Use, Lab Use Only.

LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.

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生物&药学活性

LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.
LRRK2 inhibitor 25 demonstrated exceptional on-target potency in human peripheral blood mononuclear cells, excellent off-target kinase selectivity, and good brain exposure in rats.

物理化学性质&存储条件

分子量	414.51
分子式	C24H26N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(1-(6-((R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)pyrimidin-4-yl)-1H-indazol-6-yl)spiro[2.2]pentane-1-carbonitrile

参考文献

1. David A Candito, et al. J Med Chem. 2022 Dec 22;65(24):16801-16817.

LRRK2 inhibitor 25 (LRRK2-IN-7)

生物&药学活性

物理化学性质&存储条件

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LRRK2 inhibitor 25 (LRRK2-IN-7)

生物&药学活性

物理化学性质&存储条件

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