Lu AF58786 | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : Lu AF58786

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Lu AF58786 (LuAF58786)

货号: PC-49826Not For Human Use, Lab Use Only.

Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively.

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生物&药学活性

Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively.
Lu AF58786 is a potent inhibitor of LRRK2 and G2019S that also engages alanine at position 2016 in LRRK2.
Lu AF58786 selectively inhibits LRRK2 in human PBMCs, shows high selectivity in human PBMCs using the ActivX KiNativ assays at 100 nM.|
Lu AF58786 showed inhibition of LRRK2-Ser935 phosphorylation in human PBMCs.
Lu AF58786 inhibited phosphorylation of LRRK2, Rab10 and Rab12 in cultured and immune stimulated human PBMCs.

物理化学性质&存储条件

分子量	328.38
分子式	C19H16N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((1-methyl-1H-pyrazol-3-yl)amino)-4-(m-tolyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

参考文献

1. Kenneth Thirstrup, et al. Sci Rep. 2017 Aug 31;7(1):10300.

Lu AF58786 (LuAF58786)

生物&药学活性

物理化学性质&存储条件

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Lu AF58786 (LuAF58786)

生物&药学活性

物理化学性质&存储条件

参考文献

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