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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-FX2149
FX2149

Chemical Structure : FX2149

CAS No.: 1842427-90-0

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FX2149 (FX 2149)

货号: PC-49821Not For Human Use, Lab Use Only.

FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
FX2149 potently inhibits LRRK2 GTP binding and kinase activity in vitro.
FX2149 at 100 nM concentration significantly reduced G2019S-LRRK2 phosphorylation at residues S935 and S2032 by 90% in cell-free assays.
FX2149 (100 nM) attenuated G2019S-LRRK2-induced neuronal degeneration in SH-SY5Y cells.
FX2149 (10 mg/kg) is more efficient in reducing LRRK2 GTP binding and kinase activities in transgenic mice brains than LRRK2 inhibitor 68.
FX2149 (10 mg/kg) reduced LPS-induced microglia activation and LRRK2 upregulation in mice.
FX2149 attenuates LRRK2-R1441C-induced mitochondrial and lysosomal transport impairments.

物理化学性质&存储条件

分子量 319.38
分子式 C15H17N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Propyl-3-(pyridine-3-sulfonamido)benzamide

参考文献

1. Li T, et al. PLoS One. 2015 Mar 27;10(3):e0122461.

2. Thomas JM, et al. Front Aging Neurosci. 2017 Jan 10;8:337.

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