MLi-2 |CAS:1627091-47-7 Probechem Biochemicals

Chemical Structure : MLi-2

CAS No.: 1627091-47-7

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MLi-2 (MLi2;Mli 2)

货号: PC-42142Not For Human Use, Lab Use Only.

MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).

规格	价格	库存
10 mg	￥1880	In stock
25 mg	￥3180	In stock
50 mg	￥5280	In stock
100 mg	￥8980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
MLi2 displays >295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels.
MLi2 signficantly reduces the ratio of phosphorylated Ser935 LRRK2 (pS935) to total LRRK2 in the mouse cortex, consistent with enlarged type II pneumocytes.

物理化学性质&存储条件

分子量	379.4555
分子式	C21H25N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 26 mg/mL
Chemical Name/SMILES	1H-Indazole, 3-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-, rel-

参考文献

1. Scott JD, et al. J Med Chem. 2017 Apr 13;60(7):2983-2992.

2. Fell MJ, et al. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.

3. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13;36(28):7415-27.

MLi-2 (MLi2;Mli 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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MLi-2 (MLi2;Mli 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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