| Cat. No. |
Product Name |
Information |
| PC-62372 |
SR9444
LRRK2/JNK3 inhibitor
|
SR9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK3 with IC50 of 100 nM and 12 nM respectively. |
| PC-42142 |
MLi-2
LRRK2 inhibitor
|
MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2). |
| PC-42726 |
LRRK2-IN-1
LRRK2 inhibitor
|
LRRK2-IN-1 is a potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay). |
| PC-45094 |
JH-II-127
LRRK2 inhibitor
|
JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively. |
| PC-45425 |
GNE-7915 tosylate
LRRK2 inhibitor
|
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-45424 |
GNE-7915
LRRK2 inhibitor
|
GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-22264 |
HG-10-102-01
LRRK2 inhibitor
|
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 20.3 nM and 3.2 nM, respectively. |
| PC-22263 |
CZC-25146
LRRK2 inhibitor
|
CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively. |
| PC-21889 |
MLi-2
LRRK2 inhibitor
|
MLi-2 is a potent, highly selective, orally available, brain-penetrant inhibitor of LRRK2 with IC50 of 0.76 nM, pSer935 LRRK2 IC50 of 1.4 nM. |
| PC-21888 |
EB‐42168
G2019S-LRRK2 inhibitor
|
EB‐42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2. |
| PC-21271 |
MK-1468
LRRK2 inhibitor
|
MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM. |
| PC-49820 |
BIIB122
LRRK2 inhibitor
|
BIIB122 (DNL151) is a potent, selective, CNS-penetrant LRRK2 inhibitor. |
