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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-GNE-7915
GNE-7915

Chemical Structure : GNE-7915

CAS No.: 1351761-44-8

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GNE-7915 (GNE7915, GNE 7915)

货号: PC-45424Not For Human Use, Lab Use Only.

GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.

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10 mg ￥880 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
GNE-7915 shows 1/187 kinases with 50% inhibition at 0.1 uM.
GNE-7915 possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.

物理化学性质&存储条件

分子量 443.3954
分子式 C19H21F4N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 14.33 mg/mL
Chemical Name/SMILES

Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-

参考文献

1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33.

2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.

3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.

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