GNE-7915 tosylate | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : GNE-7915 tosylate

CAS No.: 2070015-00-6

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GNE-7915 tosylate (GNE7915 tosylate, GNE 7915 tosylate)

货号: PC-45425Not For Human Use, Lab Use Only.

GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM.

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10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM.
GNE-7915 shows 1/187 kinases with 50% inhibition at 0.1 uM.
GNE-7915 possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.

物理化学性质&存储条件

分子量	615.597
分子式	C26H29F4N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-, 4-methylbenzenesulfonate (1:1)

参考文献

1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33.

2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.

3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.

GNE-7915 tosylate (GNE7915 tosylate, GNE 7915 tosylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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GNE-7915 tosylate (GNE7915 tosylate, GNE 7915 tosylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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