GSK2578215A | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : GSK2578215A

CAS No.: 1285515-21-0

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GSK2578215A (GSK-2578215A)

货号: PC-43416Not For Human Use, Lab Use Only.

GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively.

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10 mg	￥980	In stock
25 mg	￥1880	In stock
100 mg	￥5480	In stock
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生物&药学活性

GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively.
GSK2578215A shows 8-fold reduced potentcy against A2016T mutant LRRK2 (IC50=81 nM).
GSK2578215A inhibits Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 G2019S stably transfected into HEK293 cells at 0.1-0.3 uM, also induces dephosphorylation of Ser910 and 935 at 1-3 μM in the inhibitor-resistant LRRK2[A2016T+ G2019S] and LRRK2 [A2016T] mutants.
GSK2578215A induces protective autophagy in SH-SY5Y cells.

物理化学性质&存储条件

分子量	399.417
分子式	C24H18FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-

参考文献

1. Reith AD, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9.

2. Saez-Atienzar S, et al. Cell Death Dis. 2014 Aug 14;5:e1368.

GSK2578215A (GSK-2578215A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2578215A (GSK-2578215A)

生物&药学活性

物理化学性质&存储条件

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