JH-II-127

Chemical Structure : JH-II-127

CAS No.: 1700693-08-8

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货号: PC-45094Not For Human Use, Lab Use Only.

JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively.
JH-II-127 also inhibits LRRK2 A2016T with IC50 of 47.7 nM.
JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at 0.1-0.3 uM in a variety of cell types.
JH-II-127 inhibits Ser935 phosphorylation in mouse brain; orally active.

物理化学性质&存储条件

分子量	416.8615
分子式	C19H21ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-

参考文献

1. Hatcher JM, et al. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9.

JH-II-127

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物理化学性质&存储条件

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JH-II-127

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物理化学性质&存储条件

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