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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-SR9444
SR9444

Chemical Structure : SR9444

CAS No.: 1442659-77-9

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SR9444 (SR-9444)

货号: PC-62372Not For Human Use, Lab Use Only.

SR9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK3 with IC50 of 100 nM and 12 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SR9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK3 with IC50 of 100 nM and 12 nM respectively.
    SR9444 shows reasonable selectivity against a panel of 116 kinases.
    SR9444 exhibits good cell potency, inhibits LRRK2:G2019S-induced mitochondrial dysfunction in SHSY5Y cells.

    物理化学性质&存储条件

    分子量 696.849
    分子式 C39H48N6O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-((2-((6-(4-(1H-indazol-3-yl)benzamido)hexyl)amino)-2-oxoethyl)(isobutyl)amino)-2-oxoethyl)-6-methoxychromane-3-carboxamide

    参考文献

    1. Feng Y, et al. ACS Chem Biol. 2013 Aug 16;8(8):1747-54.

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