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首页-小分子抑制剂&激动剂-Autophagy-Autophagy-related Protein (Atg)-MJO445
MJO445

Chemical Structure : MJO445

CAS No.: 1968-56-5

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MJO445 (MJO-445)

货号: PC-26068Not For Human Use, Lab Use Only.

MJO445 is a small molecule ATG4B inhibitor with IC50 of 12.7 uM, inhibits ATG4B-induced conversion of LC3-I (uncleaved human ATG8) to cleaved and lipidated LC3-II and the degradation of autophagy substrate p62/SQSTM1 p62.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MJO445 is a small molecule ATG4B inhibitor with IC50 of 12.7 uM, inhibits ATG4B-induced conversion of LC3-I (uncleaved human ATG8) to cleaved and lipidated LC3-II and the degradation of autophagy substrate p62/SQSTM1 p62.
MJO445 significantly decreases the relative cell viability in GSC83, as well as GSC576 cells.
MJO445 shows markedly enhanced potency against ATG4B as a promoter of cellular autophagy, compared with NSC185058.

物理化学性质&存储条件

分子量 265.33
分子式 C15H11N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(pyridin-2-yl)quinoline-2-carbothioamide

参考文献

1. Dalton R Kim, et al. ACS Med Chem Lett. 2024 Jan 16;15(2):258-264.

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