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首页-小分子抑制剂&激动剂-Autophagy-Autophagy-related Protein (Atg)-DC-ATG4in
DC-ATG4in

Chemical Structure : DC-ATG4in

CAS No.: 690673-29-1

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DC-ATG4in

货号: PC-20716Not For Human Use, Lab Use Only.

DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.
DC-ATG4in blocked autophagy induced by Sorafenib in Hepatocellular Carcinoma (HCC) cells.
Combination of DC-ATG4in with Sorafenib synergized the cancer cell killing effect and proliferation inhibition activities on HCC cells.

物理化学性质&存储条件

分子量 418.52
分子式 C23H22N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

S=C(N1CCCCCC1)NC2=CC=C3N=C(C4=CC=CO4)C(C5=CC=CO5)=NC3=C2

参考文献

1. Yanqiu Xie, et al. Bioorg Med Chem. 2023 Apr 15;84:117262.

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