NSC 185058 |CAS:39122-38-8 Probechem Biochemicals

Chemical Structure : NSC 185058

CAS No.: 39122-38-8

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NSC 185058 (NSC185058;NSC-185058;2-Pyridinecarbothioamide)

货号: PC-60597Not For Human Use, Lab Use Only.

NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.

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10 mg	￥2580	In stock
25 mg	￥4280	In stock
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生物&药学活性

NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.
NSC 185058 directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo.
NSC 185058 markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.

物理化学性质&存储条件

分子量	215.274
分子式	C11H9N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-pyridin-2-ylpyridine-2-carbothioamide

参考文献

1. Akin D, et al. Autophagy. 2014;10(11):2021-35.

2. Huang T, et al. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.

NSC 185058 (NSC185058;NSC-185058;2-Pyridinecarbothioamide)

生物&药学活性

物理化学性质&存储条件

参考文献

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NSC 185058 (NSC185058;NSC-185058;2-Pyridinecarbothioamide)

生物&药学活性

物理化学性质&存储条件

参考文献

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