ATG12-ATG3 inhibitor 189 | ATG12-ATG3 inhibitor | Probechem Biochemicals

Chemical Structure : ATG12-ATG3 inhibitor 189

CAS No.: 333351-38-5

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ATG12-ATG3 inhibitor 189 (Compound 189)

货号: PC-20824Not For Human Use, Lab Use Only.

ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM.
ATG12-ATG3 inhibitor 189 (Compound 189) reduces the levels of lipidated LC3B (LC3B-II) relative to the unlipidated form (LC3B-I) upon induction of autophagosomes with torin1 and CQ.
ATG12-ATG3 inhibitor 189 (Compound 189) (5 uM) reduces autophagy levels and the growth of autophagy-addicted pancreatic PANC1 and NCI-H460 cell lines.
ATG12-ATG3 inhibitor 189 (Compound 189) displays a selective inhibitory effect on the growth of autophagy addicted tumor cells and inhibited secretion of IL1B/IL-1β (interleukin 1 beta) by macrophage-like cells.

物理化学性质&存储条件

分子量	327.40
分子式	C18H17NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-hydroxynaphthalen-1-yl)-2,4-dimethylbenzenesulfonamide

参考文献

1. Gal Chaim Nuta, et al. Autophagy. 2023 Feb 22;1-14.

ATG12-ATG3 inhibitor 189 (Compound 189)

生物&药学活性

物理化学性质&存储条件

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ATG12-ATG3 inhibitor 189 (Compound 189)

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物理化学性质&存储条件

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