欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Autophagy-Autophagy-related Protein (Atg)-UAMC-2526
UAMC-2526

Chemical Structure : UAMC-2526

CAS No.: 2116590-65-7

加入收藏

UAMC-2526 (UAMC2526)

货号: PC-72136Not For Human Use, Lab Use Only.

UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.
    UAMC-2526 (50-100 uM) completely inhibits proliferation of HT-29 colorectal carcinoma cells.
    UMAC-2526 inhibits autophagy in a colorectal cancer xenograft model and potentiates chemotherapy efficacy.
    UMAC-256 inhibits autophagy in a healthy mouse model, animals treated with
    compound UAMC-2526 showed lower levels of uncleaved (free) GFP, decreased LC3-II/LC3-I ratios and a marked increase of SQSTM1.
    UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments, did not inhibit autophagy in the Panc02 mouse model.

    物理化学性质&存储条件

    分子量 383.194
    分子式 C16H15BrO6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    butyl 2-bromo-3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene-8-carboxylate

    参考文献

    1. Kurdi A, et al. Biochem Pharmacol. 2017 Aug 15;138:150-162.

    2. Salado IG, et al. Eur J Med Chem. 2018 May 10;151:18-26.

    3. Takhsha FS, et al. Front Oncol. 2021 Nov 18;11:750259.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: