MCP110 |CAS:521310-51-0 Probechem Biochemicals

Chemical Structure : MCP110

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MCP110 (MCP 110)

货号: PC-62206Not For Human Use, Lab Use Only.

MCP110 is a potent Ras/Raf-1 interaction inhibitor.

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1 g		Get quote

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生物&药学活性

MCP110 is a potent Ras/Raf-1 interaction inhibitor.
MCP110 inhibits Ras-induced Raf-1 activation in human embryonic kidney 293 cells, Raf-1 and MAPK1 activities in HT1080 fibrosarcoma cells, and EGF-induced Raf-1 activation in A549 lung carcinoma cells.
MCP110 inhibits anchorage-independent growth of A549 and PANC-1 cells harboring K-ras mutation.
MCP110 causes G1 enrichment of A549 cells with the decrease of cyclin D level.
MCP110 inhibits the growth of LXFA 629 lung and SW620 colon carcinoma cells in xenograft models.

物理化学性质&存储条件

分子量	508.662
分子式	C33H36N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[3-Methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]benzenepentanamide

参考文献

1. Kato-Stankiewicz J, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.

2. Skobeleva N, et al. Mol Cancer Ther. 2007 Mar;6(3):898-906.

3. González-Pérez V, et al. J Mol Signal. 2010 Feb 23;5:2.

MCP110 (MCP 110)

生物&药学活性

物理化学性质&存储条件

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MCP110 (MCP 110)

生物&药学活性

物理化学性质&存储条件

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