| Cat. No. |
Product Name |
Information |
| PC-42871 |
Vemurafenib
B-Raf V600E inhibitor
|
Vemurafenib (PLX4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM). |
| PC-63027 |
SB-699393
B-Raf inhibitor
|
SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
| PC-62702 |
EBI-907
B-Raf V600E inhibitor
|
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM. |
| PC-62206 |
MCP110
Ras/Raf-1 inhibitor
|
MCP110 is a potent Ras/Raf-1 interaction inhibitor. |
| PC-61974 |
REDX-05358
RAF inhibitor
|
REDX-05358 is a potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively. |
| PC-61525 |
XL-281
RAF inhibitor
|
XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models. |
| PC-61364 |
Belvarafenib
RAF inhibitor
|
Belvarafenib (HM95573, GDC-5573) is a potent, selective RAF inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF V600E and CRAF, respectively. |
| PC-70025 |
BRAF inhibitor 13
B-Raf inhibitor
|
A potent and selective B-Raf inhibitor with IC50 of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
| PC-42645 |
GW 5074
c-Raf inhibitor
|
GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT. |
| PC-42446 |
Sorafenib tosylate
RAF inhibitor
|
Sorafenib (Bay 43-9006) tosylate is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively. |
| PC-42445 |
Sorafenib
RAF inhibitor
|
Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively. |
| PC-42483 |
RAF265
Raf/VEGFR-2 inhibitor
|
RAF265 (CHIR265) is a potent, oral, dual Raf/VEGFR-2 inhibitor with IC50 of 3-60 nM for C-Raf/B-Raf/B-Raf V600E, EC50 of 30 nM for VEGFR2 phosphorylation. |
