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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-SB-699393
SB-699393

Chemical Structure : SB-699393

CAS No.: 1348166-93-7

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SB-699393 (SB699393)

货号: PC-63027Not For Human Use, Lab Use Only.

SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM.
    SB-699393 possesses enhanced CNS penetration (BB ratio=0.8:1) compared with SB-590885.

    物理化学性质&存储条件

    分子量 403.482
    分子式 C24H25N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-((5-(5-(morpholinomethyl)-2-(pyridin-4-yl)furan-3-yl)-2,3-dihydro-1H-inden-1-ylidene)amino)methanol

    参考文献

    1. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.

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