RRD-251 |CAS:131916-62-6 Probechem Biochemicals

Chemical Structure : RRD-251

CAS No.: 131916-62-6

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RRD-251 (RRD251)

货号: PC-35100Not For Human Use, Lab Use Only.

RRD-251 is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.

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25 mg	￥880	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

RRD-251 is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.
RRD-251 inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity.
RRD-251 inhibits anchorage-dependent and anchorage-independent growth of human cancer cells.
RRD-251 significantly inhibits tumor growth in tumors with functional Rb in vivo.

物理化学性质&存储条件

分子量	235.126
分子式	C8H8Cl2N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-dichlorobenzyl carbamimidothioate

参考文献

1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8.

2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41.

3. Treviño JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34.

4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418.

RRD-251 (RRD251)

生物&药学活性

物理化学性质&存储条件

参考文献

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RRD-251 (RRD251)

生物&药学活性

物理化学性质&存储条件

参考文献

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