ZM 336372 |CAS:208260-29-1 Probechem Biochemicals

Chemical Structure : ZM 336372

CAS No.: 208260-29-1

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ZM 336372 (ZM336372;ZM-336372)

货号: PC-43507Not For Human Use, Lab Use Only.

ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1680	In stock
100 mg	￥4480	In stock
500 mg		Get quote

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生物&药学活性

ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2.
ZM 336372 suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18.
ZM 336372 blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.

物理化学性质&存储条件

分子量	389.45
分子式	C23H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-

参考文献

1. Hall-Jackson CA, et al. Chem Biol. 1999 Aug;6(8):559-68.

2. Van Gompel JJ, et al. Mol Cancer Ther. 2005 Jun;4(6):910-7.

3. Kappes A, et al. J Surg Res. 2006 Jun 1;133(1):42-5.

4. Kunnimalaiyaan M, et al. Surgery. 2007 Dec;142(6):959-64; discussion 959-64.

ZM 336372 (ZM336372;ZM-336372)

生物&药学活性

物理化学性质&存储条件

参考文献

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ZM 336372 (ZM336372;ZM-336372)

生物&药学活性

物理化学性质&存储条件

参考文献

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