L-779450 |CAS:303727-31-3 Probechem Biochemicals

Chemical Structure : L-779450

CAS No.: 303727-31-3

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L-779450 (L779450)

货号: PC-43208Not For Human Use, Lab Use Only.

L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.
L-779450 suppresses DNA synthesis and induced apoptosis in hematopoietic FDC-P1 cells transformed to grow in response to either Raf-1 or A-Raf.
L-779,450 is less effective on B-Raf- or MEK1-responsive cells, also suppresses DNA synthesis and induces apoptosis in Raf-responsive cells and the effects are more significant on Raf-responsive compared to cytokine-mediated growth.

物理化学性质&存储条件

分子量	347.7977
分子式	C20H14ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-

参考文献

1. Shelton JG, et al. Leukemia. 2003 Sep;17(9):1765-82.

2. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.

3. McKay MM, et al. Curr Biol. 2011 Apr 12;21(7):563-8.

4. Berger A, et al. J Invest Dermatol. 2014 Feb;134(2):430-440.

L-779450 (L779450)

生物&药学活性

物理化学性质&存储条件

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L-779450 (L779450)

生物&药学活性

物理化学性质&存储条件

参考文献

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