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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-CCT241161
CCT241161

Chemical Structure : CCT241161

CAS No.: 1163719-91-2

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CCT241161 (CCT 241161, CCT-241161)

货号: PC-63267Not For Human Use, Lab Use Only.

CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively)..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively).

    物理化学性质&存储条件

    分子量 541.62
    分子式 C28H27N7O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea

    参考文献

    1. Girotti MR, et al. Cancer Cell. 2015 Jan 12;27(1):85-96.

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