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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-Vemurafenib
Vemurafenib

Chemical Structure : Vemurafenib

CAS No.: 918504-65-1

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Vemurafenib (PLX4032, RG7204, RO5185426)

货号: PC-42871Not For Human Use, Lab Use Only.

Vemurafenib (PLX4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM).

规格 价格 库存 数量
25 mg ￥680 In stock
100 mg ￥1280 In stock
250 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vemurafenib (PLX4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM).
Vemurafenib (PLX4032) potently inhibits proliferation of a panel of tumor cell lines, selectively blocks the RAF/MEK/ERK pathway in BRAF mutant cells.
Vemurafenib (PLX4032) causes tumor regressions and improves animal survival in tumor xenograft models of BRAF(V600E)-expressing melanoma.

物理化学性质&存储条件

分子量 489.9221
分子式 C23H18ClF2N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 6.2 mg/mL
Chemical Name/SMILES

1-Propanesulfonamide, N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

参考文献

1. Bollag G, et al. Nature. 2010 Sep 30;467(7315):596-9.

2. Joseph EW, et al. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8.

3. Yang H, et al. Cancer Res. 2010 Jul 1;70(13):5518-27.

4. Søndergaard JN, et al. J Transl Med. 2010 Apr 20;8:39.

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