EBI-907 |CAS:1581764-31-9 Probechem Biochemicals

Chemical Structure : EBI-907

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EBI-907 (EBI907)

货号: PC-62702Not For Human Use, Lab Use Only.

EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.

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生物&药学活性

EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
EBI-907 shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines.
EBI-907 demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.

物理化学性质&存储条件

分子量	506.95
分子式	C23H21ClF2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide

参考文献

1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23.

EBI-907 (EBI907)

生物&药学活性

物理化学性质&存储条件

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EBI-907 (EBI907)

生物&药学活性

物理化学性质&存储条件

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