Belvarafenib |CAS:1446113-23-0 Probechem Biochemicals

Chemical Structure : Belvarafenib

CAS No.: 1446113-23-0

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Belvarafenib (HM95573, GDC-5573, RG6185)

货号: PC-61364Not For Human Use, Lab Use Only.

Belvarafenib (HM95573, GDC-5573) is a potent, selective RAF inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF V600E and CRAF, respectively.

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1 mg (Free Sample)	￥280	In stock
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
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生物&药学活性

Belvarafenib (HM95573, GDC-5573) is a potent, selective RAF inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF V600E and CRAF, respectively.
Belvarafenib (HM95573, GDC-5573) inhibits cell proliferation of A375 (BRAF V600E) and SK-MEL-30 (NRAS Q61K) with IC50 of 57 and 24 nM, also inhibits the phosphorylations of MEK and ERK downstream kinases in mutant BRAF and mutant NRAS melanoma cells.
Belvarafenib (HM95573, GDC-5573) shows the excellent antitumor activity in mouse models xenografted with both of BRAF mutation cell lines (e.g. A375 and SK-MEL-28) and NRAS mutation cell lines.

物理化学性质&存储条件

分子量	478.93
分子式	C23H16ClFN6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-N-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide

参考文献

1. InHwan Bae, et al. Antitumor activity of the selective RAF inhibitor HM95573 in melanoma. AACR 2015. DOI: 10.1158/1538-7445.AM2015-2606

Belvarafenib (HM95573, GDC-5573, RG6185)

生物&药学活性

物理化学性质&存储条件

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Belvarafenib (HM95573, GDC-5573, RG6185)

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