RAF265 |CAS:927880-90-8 Probechem Biochemicals

Chemical Structure : RAF265

CAS No.: 927880-90-8

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RAF265 (CHIR-265;RAF 265;RAF-265;CHIR265)

货号: PC-42483Not For Human Use, Lab Use Only.

RAF265 (CHIR265) is a potent, oral, dual Raf/VEGFR-2 inhibitor with IC50 of 3-60 nM for C-Raf/B-Raf/B-Raf V600E, EC50 of 30 nM for VEGFR2 phosphorylation.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RAF265 (CHIR265) is a potent, oral, dual Raf/VEGFR-2 inhibitor with IC50 of 3-60 nM for C-Raf/B-Raf/B-Raf V600E, EC50 of 30 nM for VEGFR2 phosphorylation.
RAF265 (CHIR265) blocks Raf-MEK-ERK signalling and significantly enhances TRAIL sensitivity in NCI-H727 and CM insulinoma cells.
RAF265 (CHIR265) inhibits cell proliferation with IC50 of 0.83-5.54 uM in CRC cells, demonstrates significant anti-tumor activity in tumors of xenograft models.

物理化学性质&存储条件

分子量	518.4139
分子式	C24H16F6N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 26 mg/mL
Chemical Name/SMILES	1H-Benzimidazol-2-amine, 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-

参考文献

1. Mordant P, et al. Mol Cancer Ther. 2010 Feb;9(2):358-68.

2. Zitzmann K, et al. Endocr Relat Cancer. 2011 Mar 21;18(2):277-85.

3. Su Y, et al. Clin Cancer Res. 2012 Apr 15;18(8):2184-98.

4. Chen J, et al .Cancer Res. 2011 Jun 15;71(12):4280-91.

RAF265 (CHIR-265;RAF 265;RAF-265;CHIR265)

生物&药学活性

物理化学性质&存储条件

参考文献

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RAF265 (CHIR-265;RAF 265;RAF-265;CHIR265)

生物&药学活性

物理化学性质&存储条件

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