XL-281 |CAS:870603-16-0 Probechem Biochemicals

Chemical Structure : XL-281

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XL-281 (BMS 908662;XL281)

货号: PC-61525Not For Human Use, Lab Use Only.

XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models.

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生物&药学活性

XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models.
XL-281 (BMS 908662) demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis.

物理化学性质&存储条件

分子量	462.89
分子式	C24H19ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, [5-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester (9CI)

参考文献

1. Callahan MK, et al. Cancer Immunol Res. 2014 Jan;2(1):70-9.

2. Belum VR, et al. Cancer. 2015 Jan 1;121(1):60-8.

3. Dickson MA, et al. Invest New Drugs. 2015 Apr;33(2):349-56.

XL-281 (BMS 908662;XL281)

生物&药学活性

物理化学性质&存储条件

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XL-281 (BMS 908662;XL281)

生物&药学活性

物理化学性质&存储条件

参考文献

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