Sorafenib |CAS:284461-73-0 Probechem Biochemicals

Chemical Structure : Sorafenib

CAS No.: 284461-73-0

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Sorafenib (Bay 43-9006, Bay43-9006)

货号: PC-42445Not For Human Use, Lab Use Only.

Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.

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10 mg (Free Sample)	￥280	In stock
100 mg	￥780	In stock
250 mg	￥1280	In stock
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生物&药学活性

Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
Sorafenib (Bay 43-9006) also demonstrates potent inhibition of certain proangiogenic RTKs, including VEGFR-2, PDGFR-β, VEGFR-3, Flt-3, c-Kit (IC50<100 nM).
Sorafenib (Bay 43-9006) exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.

物理化学性质&存储条件

分子量	464.825
分子式	C21H16ClF3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-

参考文献

1. Wilhelm SM, et al. Cancer Res. 2004 Oct 1;64(19):7099-109.

2. Carlomagno F, et al. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34.

4. Lyons JF, et al. Endocr Relat Cancer. 2001 Sep;8(3):219-25.

Sorafenib (Bay 43-9006, Bay43-9006)

生物&药学活性

物理化学性质&存储条件

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Sorafenib (Bay 43-9006, Bay43-9006)

生物&药学活性

物理化学性质&存储条件

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