REDX-05358 |CAS:1884226-20-3 Probechem Biochemicals

Chemical Structure : REDX-05358

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REDX-05358 (REDX 05358;REDX05358)

货号: PC-61974Not For Human Use, Lab Use Only.

REDX-05358 is a potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively.

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生物&药学活性

REDX-05358 is a potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively.
REDX-05358 demonstrates high selectivity profile against a panel of 468 kinases, exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers.
REDX-05358 not only inhibits MAPK signalling in BRAF V600E mutant tumor cells, but also in those harbouring NRAS and KRAS mutations.
REDX-05358 exhibits in vivo efficacy in BRAF V600E CRC xenograft model.

物理化学性质&存储条件

分子量	472.929
分子式	C26H21ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[3-[5-(2-Chlorophenyl)-1H-imidazol-2-yl]chroman-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one

参考文献

1. Helen Mason, et al. AACR, Abstract 5160.

REDX-05358 (REDX 05358;REDX05358)

生物&药学活性

物理化学性质&存储条件

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REDX-05358 (REDX 05358;REDX05358)

生物&药学活性

物理化学性质&存储条件

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