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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-Erianin
Erianin

Chemical Structure : Erianin

CAS No.: 95041-90-0

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Erianin

货号: PC-21593Not For Human Use, Lab Use Only.

Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥2880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway.
Erianin inhibits constitutive activation of MAPK signaling pathway through suppressing CRAF and MEK1/2 but not BRAF kinase activity.
Erianin inhibits proliferation in BRAF V600E or RAS mutant cell lines.
Erianin suppresses either BRAF V600E or RAS mutant cell growth in CDX model.

物理化学性质&存储条件

分子量 318.37
分子式 C18H22O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methoxy-5-(3,4,5-trimethoxyphenethyl)phenol

参考文献

1. Wang P, et al. Signal Transduct Target Ther. 2023;8:96.

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