Omzirafenib (LUT014, LUT-014) | BRAF inhibitor | Probechem Biochemicals

Chemical Structure : LUT014

CAS No.: 2274819-46-2

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LUT014 (Omzirafenib, LUT-014)

货号: PC-27489Not For Human Use, Lab Use Only.

Omzirafenib (LUT014, LUT-014) is a potent and specific, topical BRAF kinase inhibitor with IC50 of 13.3 nM and 11.7 nM for BRAF-V600E and WT BRAF respectively, paradoxically activates mitogen-activated protein kinase (MAPK).

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

Omzirafenib (LUT014, LUT-014) is a potent and specific, topical BRAF kinase inhibitor with IC50 of 13.3 nM and 11.7 nM for BRAF-V600E and WT BRAF respectively, paradoxically activates mitogen-activated protein kinase (MAPK).
LUT014 shows clear selectivity in vitro kinase inhibition profiling study against 59 human recombinant kinases.
inhibits proliferation of the KRASG12C-mutated human pancreatic cancer cell line MIA-PaCa-2.
LUT014 overrides the MAPK pathway inhibition, resulting in an increase in phosphorylated ERK1/2 (pERK) signaling in skin cells.
LUT014 could improve skin toxicities induced by EGFR inhibitors.

物理化学性质&存储条件

分子量	528.50
分子式	C27H19F3N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N5-(3-(7H-Purin-6-yl)pyridin-2-yl)-6-methyl-N1-(3-(trifluoromethoxy)phenyl)isoquinoline-1,5-diamine

参考文献

1. Lacouture ME, et al. Cancer Discov. 2021 Sep;11(9):2158-2167.

LUT014 (Omzirafenib, LUT-014)

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物理化学性质&存储条件

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LUT014 (Omzirafenib, LUT-014)

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物理化学性质&存储条件

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