ELV-3111 | RAF inhibitor | Probechem Biochemicals

Chemical Structure : ELV-3111

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ELV-3111 (ELV3111)

货号: PC-28573Not For Human Use, Lab Use Only.

ELV-3111 is a next-generation, potent, and selective Type 1 RAF inhibitor, inhibits both monomeric and dimeric RAF.

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100 mg		Get quote

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生物&药学活性

ELV-3111 is a next-generation, potent, and selective Type 1 RAF inhibitor, inhibits both monomeric and dimeric RAF.
ELV-3111 binds BRAF in a DFG-IN/αC-helix-IN (Type 1) binding conformation
ELV-3111 is 17 to 844-fold more selective for BRAF over any of the potential off-target kinases.
ELV-3111 potently binds ARAF, BRAF and CRAF, with similar affinity to the Type 2 RAFi Naporafenib.
ELV-3111 potently inhibits cell growth and MAPK signaling in both monomeric and dimeric BRAF(V600E) cells.
ELV-3111 is highly effective in suppressing growth and MAPK signaling of BRAF(MUT)/RAS(MUT) cells.
ELV-3111 achieves potent and selective MAPK and growth suppression in RAF dimer-driven tumor models.
ELV-3111 potently inhibits BRAF class I/II/III-, CRAF-, and RAS-mutant cancer models in vitro and in vivo and overcomes multiple mechanisms of resistance to current RAF inhibitors, including BRAF(V600E) splice variants and RAS co-mutations.

物理化学性质&存储条件

分子量	420.45
分子式	C22H21FN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1C(F)C1)NC2=CC(N3C(C(C4=C(C)C=C(C(CC)O)N=C4)=C5)=NC=N3)=C5C=N2

参考文献

1. Desaunay M, et al. bioRxiv [Preprint]. 2026 Oct 6:2026.10.05.756774.

ELV-3111 (ELV3111)

生物&药学活性

物理化学性质&存储条件

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ELV-3111 (ELV3111)

生物&药学活性

物理化学性质&存储条件

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