| Cat. No. |
Product Name |
Information |
| PC-23977 |
EPB-113
Coronavirus inhibitor
|
EPB-113 is a potent replication inhibitor of HCoV-229E with EC50 of 0.48 uM, also suppresses SARS-CoV-2, binds to hexameric nsp15 protein. |
| PC-23891 |
TKB272
SARS-CoV-2 Mpro inhibitor
|
TKB272 is a potent, selective inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.7 nM, effectively blocks the infectivity and replication of SARS-CoV-2 strains (SARS-CoV-2 WK-521, EC50=7.0 nM, VeroE6 cell). |
| PC-23632 |
TDI-015051
SARS-CoV-2 NSP14 inhibitor
|
TDI-015051 is a highly potent, specific inhibitor of SARS-CoV-2 NSP14 RNA cap methyltransferase with Kd of 61 pM and IC50 of <0.15 nM, inhibits viral mRNA translation. |
| PC-23595 |
SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2
nsp12 NiRAN domain inhibitor
|
NCI-2 is a small molecule inhibitor of SARS-CoV-2 nsp12 NiRAN domain, covalently binds to an active site cysteine (Cys53) in the NiRAN domain, inhibiting nsp12-dependent AMPylation of nsp9 with IC50 of 4.3 uM. |
| PC-23545 |
GZNL-P36
SARS-CoV-2 PLpro inhibitor
|
GZNL-P36 is a potent, selective and orally bioavailable SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.45 nM, ITC Kd value of 24.6 nM. |
| PC-23503 |
AB-343
SARS-CoV-2 Mpro inhibitor
|
AB-343 is a potent, selective, reversible covalent inhibitor of SARS-CoV-2 Mpro with Ki/IC50 of 2.8/8 nM, inhibits SARS-CoV-2 in Vero E6 cells and SARS-CoV-2-infected human lung cells (hACE2-A549) with EC50 of 18 nM. |
| PC-23483 |
TMPRSS2 inhibitor BC-11 hydrobromide
TMPRSS2 inhibitor
|
TMPRSS2 inhibitor BC-11 hydrobromide is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay. |
| PC-23384 |
Jun12682
SARS-CoV-2 PLpro inhibitor
|
Jun12682 is a potent SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki/IC50 values of 37.7/106.8 nM. |
| PC-23375 |
NZ-804
SARS-CoV-2 Mpro inhibitor
|
NZ-804 is a potent, selective, non-peptidic, non-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 9 nM and antiviral EC50 of 14 nM. |
| PC-23359 |
ATV014
SARS-CoV-2 RdRp inhibitor
|
ATV014 (SHEN26) is a potent, orally active anti-SARS-CoV-2 nucleoside compound with EC50 of 0.48 uM against SARS-CoV-2 replicon, inhibits SARS-CoV-2 RdRp. |
| PC-23213 |
TL1228
GRP78 inhibitor
|
TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1. |
| PC-22984 |
PF-07957472
SARS-CoV-2 PLpro inhibitor
|
PF-07957472 is a potent, selective, and orally available SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki of 2 nM, exhibits cell antiviral potency in Vero E6 cells with EC50 of 147 nM. |
