MI-09 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : MI-09

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MI-09 (SARS-CoV-2 Mpro inhibitor MI-09)

货号: PC-72200Not For Human Use, Lab Use Only.

MI-09 (SARS-CoV-2 Mpro inhibitor MI-09) is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 15.2 nM.

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100 mg		Get quote

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生物&药学活性

MI-09 (SARS-CoV-2 Mpro inhibitor MI-09) is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 15.2 nM.
MI-09 dose-dependently protected SARS-CoV-2-infected Vero E6 cells from death with EC50 of 0.86 uM.
MI-09 inhibited SARS-CoV-2 virus replication in HPAEpiC cells with EC50 of 1.2 nM in RT-qPCR assays.
MI-09 (20 mg kg–1 day–1, p.o. or i.p.) reduced lung viral loads and lung lesions in a SARS-CoV-2 infection transgenic mouse model.

物理化学性质&存储条件

分子量	511.498
分子式	C24H28F3N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-6,6-dimethyl-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-3-(2-(4-(trifluoromethoxy)phenoxy)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide

参考文献

1. Qiao J, et al. Science. 2021 Mar 26;371(6536):1374-1378.

MI-09 (SARS-CoV-2 Mpro inhibitor MI-09)

生物&药学活性

物理化学性质&存储条件

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MI-09 (SARS-CoV-2 Mpro inhibitor MI-09)

生物&药学活性

物理化学性质&存储条件

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