SARS-CoV-2 Mpro inhibitor 11b

Chemical Structure : SARS-CoV-2 Mpro inhibitor 11b

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货号: PC-72202Not For Human Use, Lab Use Only.

SARS-CoV-2 Mpro inhibitor 11b is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 40 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SARS-CoV-2 Mpro inhibitor 11b is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 40 nM.
Mpro inhibitor 11b exhibited good anti-SARS-CoV-2-infection activity in cell culture with EC50 value 0.72 uM using plaque-reduction assay, without significant cytotoxicity (CC50>100 uM).
Mpro inhibitor 11b covalently bound to cysteine 145 of Mpro, showed good pharmacokinetic properties in vivo.

物理化学性质&存储条件

分子量	464.497
分子式	C25H25FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2- yl)amino)propan-2-yl)-1H-indole-2-carboxamide

参考文献

1. Wenhao Dai, et al. Science. 2020 Jun 19;368(6497):1331-1335.