Chemical Structure : SARS-CoV-2 NSP14 inhibitor C10
CAS No.:
SARS-CoV-2 NSP14 inhibitor C10
货号: PC-25647Not For Human Use, Lab Use Only.
SARS-CoV-2 NSP14 inhibitor C10 is a potent, selective non-nucleoside inhibitor of SARS-CoV-2 nonstructural protein 14 (NSP14) with IC50 of 0.34 uM, exhibits potent antiviral activity and reverses NSP14-driven host modulation.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
SARS-CoV-2 NSP14 inhibitor C10 is a potent, selective non-nucleoside inhibitor of SARS-CoV-2 nonstructural protein 14 (NSP14) with IC50 of 0.34 uM, exhibits potent antiviral activity and reverses NSP14-driven host modulation.
C10 targets NSP14 S-adenosylmethionine (SAM)-binding pocket.
C10 inhibits original SARS-CoV-2 and Delta variant with EC50 values of 0.31 µM and 0.50 µM, respectively, and inhibits the Omicron variant reached up to 64 nM with low cytotoxicity (CC50 > 100 uM).
C10 inhibits HCoV-OC43 infection in A549-ACE2 cells with an EC50 value of 4.36 µM, while the inhibition of HCoV-229E infection is negligible.
C10 inhibits SARS-CoV-2 at the replication stage, suppresses viral translation and exhibits immunostimulatory effect.
C10 reverses NSP14-mediated host transcriptome modulation.
C10 (70 mg/kg, i,p., 5% dimethyl sulfoxide and 95% cyclodextrin solution) demonstrates antiviral efficacy in K18-hACE2 transgenic mouse model.
物理化学性质&存储条件
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分子量
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545.54
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分子式
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C24H22F3N7O3S
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-(9H-purin-6-yl)piperidin-4-yl)-3-((4-(trifluoromethyl)phenyl)sulfonamido)benzamide
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参考文献
1. Luo M, et al. Nat Commun. 2025 Nov 3;16(1):9671.
