SRC-1 inhibitor 10

Chemical Structure : SRC-1 inhibitor 10

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货号: PC-27676Not For Human Use, Lab Use Only.

SRC-1 inhibitor 10 is a small molecule SARS-CoV-2 replication inhibitor targeting host lipogenesis, potently inhibits replication of both the prototypic and BA.1 variants with EC50 of 0.9 and 0.5 uM respectively, binds to and promotes degradation of nuclear receptor coactivator 1 (NCOA1, SRC-1).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SRC-1 inhibitor 10 is a small molecule SARS-CoV-2 replication inhibitor targeting host lipogenesis, potently inhibits replication of both the prototypic and BA.1 variants with EC50 of 0.9 and 0.5 uM respectively, binds to and promotes degradation of nuclear receptor coactivator 1 (NCOA1, SRC-1).
SRC-1 inhibitor 10 (8 uM) inhibit SARS-CoV-2 infection primarily at the post-entry stage rather than at the entry stage.
SRC-1 inhibitor 10 suppresses SARS-CoV-2 replication by inhibiting viral RNA replication and disrupting the architecture of eplication organelles (ROs).
SRC-1 inhibitor 10 inhibits viral replication primarily through interference with free fatty acid synthesis.
SRC-1 inhibitor 10 (12 mg/kg) suppresses viral replication and alleviates lung pathology in a Syrian hamster infection model.

物理化学性质&存储条件

分子量	338.23
分子式	C17H17Cl2NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(tert-butyl)-2-hydroxyphenyl)-3,5-dichlorobenzamide

参考文献

1. Zhang X, et al. iScience. 2026 Aug 6;29(8):117111.