CMX990 | SARS-CoV-2 3CLpro inhibitor | Probechem Biochemicals

Chemical Structure : CMX990

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CMX990 (CMX 990)

货号: PC-21780Not For Human Use, Lab Use Only.

CMX990 is a potent, selective and covalent SARS-CoV-2 3CLpro inhibitor with IC50 of 23.4 nM, exhibits good potency (EC50=37 nM) in HeLa-ACE2 SARS-CoV-2 assays.

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生物&药学活性

CMX990 is a potent, selective and covalent SARS-CoV-2 3CLpro inhibitor with IC50 of 23.4 nM, exhibits good potency (EC50=37 nM) in HeLa-ACE2 SARS-CoV-2 assays.
CMX990 displays in vitro activity in a HeLa-ACE2 cell culture model of SARS-CoV-2 infection provided a mean antiviral EC50/90 of 37/90 nM, with no detectable cytotoxicity.
CMX990 displays no activity against human peptidase selectivity panel, Cathepsin B/K/L/L2/S (All IC50>1 uM).
CMX990 potently and reproducibly inhibits the replication of eight SARS-CoV-2 variants tested, including alpha, delta, and omicron.
CMX990 also shows activity versus other betacoronaviruses (e.g., HCoV-OC43) as well as alphacoronaviruses (e.g., HCoV-229E) in live virus assays.
CMX990 performs 5× superior to nirmatrelvir in ALI-HBECs with a EC50/90 = 5.3/9.6 nM, having up to a 3-log reduction in viral load (72 h post-infection) when treated at 370 nM.

物理化学性质&存储条件

分子量	491.51
分子式	C22H32F3N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-((R)-2-Hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide

参考文献

1. Dayan Elshan NGR, et al. J Med Chem. 2024 Feb 9. doi: 10.1021/acs.jmedchem.3c01938.

CMX990 (CMX 990)

生物&药学活性

物理化学性质&存储条件

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CMX990 (CMX 990)

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物理化学性质&存储条件

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