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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-MAVDA-K-256
MAVDA-K-256

Chemical Structure : MAVDA-K-256

CAS No.:

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MAVDA-K-256

货号: PC-28781Not For Human Use, Lab Use Only.

MAVDA-K-256 is a potent and selective inhibitor of SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (MTase) NSP14 with IC50 of <0.15 nM, inhibits SARS-CoV-2 replication with IC50 of 24.6 nM in Huh-7.5 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MAVDA-K-256 is a potent and selective inhibitor of SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (MTase) NSP14 with IC50 of <0.15 nM, inhibits SARS-CoV-2 replication with IC50 of 24.6 nM in Huh-7.5 cells.
MAVDA-K-256 engages NSP14 through the formation of a ternary complex with S-adenosyl-l-homocysteine, potently inhibiting its MTase activity.
MAVDA-K-256 demonstrates broad-spectrum antiviral activity against diverse hCoVs without targeting the host mRNA cap MTase.
MAVDA-K-256 inhibits the biochemical MTase activity of NSP14 proteins of hCoVs of different genera of the Coronaviridae family, with IC50 values of 18.1 and 8.4 nM (MERS), 11.9 and 5.6 nM (229E).
MAVDA-K-256 shows no inhibitory effects against a broad panel of 39 RNA, DNA, or protein MTases up to 10 uM.
MAVDA-K-256 demonstrates potent antiviral activity against α-hCoV-NL63 (EC50 = 0.72 μM) and α-hCoV-229E (EC50 = 1.22 μM), as well as β-hCoV-OC43 (EC50 = 0.2 μM), respectively.
MAVDA-K-256 shows antiviral efficacy in a K18-hACE2 transgenic mouse model of SARS-CoV-2 infection.

物理化学性质&存储条件

分子量 466.49
分子式 C23H19FN4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-1-methyl-N-(3-methyl-4-(6-methyloxazolo[5,4-c]pyridin-2-yl)phenyl)-2-oxoindoline-5-sulfonamide

参考文献

1. Meyer C, et al. J Med Chem. 2026 Nov 12;69(21):25760-25776.

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