| Cat. No. |
Product Name |
Information |
| PC-27512 |
MAT2A inhibitor ZS34
MAT2A inhibitor
|
MAT2A inhibitor ZS34 is a potent, selective, and orally bioavailable MAT2A inhibitor with IC50 of 13.7 nM. |
| PC-27508 |
Tazbentetol
Synaptic regenerative agent
|
Tazbentetol (SPG302) is a pegylated benzothiazole derivative and synaptic regenerative small molecule, targets the cytoskeleton and induces the formation of new glutamatergic synapses. |
| PC-27505 |
JXL069
MPC inhibitor
|
Suvomipic (JXL069) is a potent, small molecule mitochondrial pyruvate carrier (MPC) inhibitor with IC50 of 42.8 nM. |
| PC-27499 |
AKBA
MAT2A inhibitor
|
AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties. |
| PC-27497 |
SARM1 inhibitor MY-13B
SARM1 inhibitor
|
SARM1 inhibitor MY-13B is a stereoselective, covalent SARM1 inhibitor, site-specifically engage C311 in SARM1. |
| PC-27492 |
Rexipictor
Polycystin-1 corrector
|
Rexipictor (VX-407) is a first-in-class small molecule Polycystin-1 (Polycystin 1, PC1, PKD1) corrector, corrects inappropriate PC1 folding to abate cystogenesis and eGFR decline, shows potential for treatment of autosomal dominant polycystic kidney disease (ADPKD). |
| PC-27442 |
FSG67
GPAT inhibitor
|
FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1. |
| PC-27404 |
Alcedaplin
APOL1 inhibitor
|
Alcedaplin (MZE829) is a small molecule inhibitor of apolipoprotein L1 (APOL1) function, blocks APOL1 pore function and ameliorate manifestations of APOL1-mediated kidney disease (AMKD). |
| PC-27294 |
LRPPRC inhibitor 3o
LRPPRC inhibitor
|
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation. |
| PC-27293 |
FKA-9i
LRPPRC-YBX1-RPN1 inhibitor
|
FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability. |
| PC-27273 |
PBITE-1
ERG PNT domain binder
|
PBITE-1 is a small molecule that selectively binds ERG N-terminal Pointed (PNT) domain with Kd of 264 uM in BLI assays, directly engages ERG, selectively inhibits proliferation and invasion, and induces apoptosis in ERG-driven prostate and hematologic malignancies. |
| PC-27270 |
XL20
TDP-43 inhibitor
|
XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM. |
