| Cat. No. |
Product Name |
Information |
| PC-27270 |
XL20
TDP-43 inhibitor
|
XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM. |
| PC-27255 |
Dihydroberberine
483-15-8
|
Dihydroberberine (dhBBR) is a berberine derivative that inhibit mitochondrial respiratory complex I, improves whole-body insulin sensitivity through increased AMPK activity, exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways. |
| PC-27253 |
TBC1D2 inhibitor G2
TBC1D2 inhibitor
|
TBC1D2 inhibitor G2 is a small molecule TBC1 domain family member 2 (TBC1D2) inhibitor with SPR KD of 0.4 uM, and IC50 of 80 nM in HCCLM3 cells, induces selective autophagic cell death. |
| PC-27242 |
Elamipretide acetate
Antioxidant tetrapeptide
|
Elamipretide acetate (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types. |
| PC-27237 |
CD73 inhibitor Compound 73
CD73 inhibitor
|
CD73 inhibitor Compound 73 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (ecto-5′-nucleotidase, eN) with IC50 of 12 nM. |
| PC-27230 |
MI-1148
Furin inhibitor
|
MI-1148 is a potent, peptidomimetic furin inhibitor with Ki of 5.5 pM, has significant protective effect against anthrax and diphtheria toxin, shows potent anti-infectious activity against H5N1 and H7N1 avian influenza viruses, West Nile and Dengue virus. |
| PC-27211 |
MEISi-3
MEIS2 inhibitor
|
MEISi-3 is a small molecule MEIS2 inhibitor targeting MEIS2 proteins effectively along with MEIS1, exhibits potent growth inhibition with IC50 of 0.1 μM in SK-BR-3 cells. |
| PC-27204 |
Semax
Neuroactive peptide
|
Semax is a BBB-penetrable, synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10), can form stable complexes with Cu2+, has immunomodulatory, nootropic and neuroprotective activities. |
| PC-27197 |
DHPS inhibitor GC7
DHPS inhibitor
|
GC7 (N1-guanyl-1,7-diaminoheptane) is a high affinity, effective deoxyhypusine synthase (DHPS) inhibitor with Ki of 10 nM, inhibits spermidine-dependent hypusine-eIF5A activation. |
| PC-27196 |
FPTP
NEK9 inhibitor
|
FPTP is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 3.64 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.7 uM and 22.8 uM. |
| PC-27195 |
MIPO
NEK9 inhibitor
|
MIPO is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 7.72 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.8 uM and 19.7 uM. |
| PC-27194 |
ICCB280
C/EBPalpha agonist
|
ICCB280 is a specific small molecule C/EBPalpha (C/EBPα) agonist, induces myeloid differentiation of leukemia cell lines by increasing expression of C/EBPα and C/EBPε, and decreasing expression of c-Myc. |
